The Cowboys are hosting a Thanksgiving game for the 40th consecutive season and making their 50th Turkey Day appearance. The Chargers, on the other hand, haven’t played on Thanksgiving since 1969, when they were an AFL team and beat the Houston Oilers, 21-17. Dallas is without suspended running
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |