The San Diego Chargers figured the formula for turning their season around included holding onto the ball and getting a tide-turning takeaway on special teams. They did all that and much more in handing the Denver Broncos their worst home loss since 1966 with a 41-3 drubbing fueled by reigning MVP LaDainian Tomlinson and his trusty backup, Michael Turner.
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |