The Los Angeles Chargers and Detroit Lions got off to solid starts in their openers, building double-digit leads in the second half before blowing them and going to overtime. Los Angeles led Indianapolis by 15 points midway through the third quarter and salvaged a victory on Austin Ekeler’s third
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
