The Bills (6-1) enter the NFL season as the outright betting favorite for the first time since 1991, followed by the Buccaneers, Chiefs, Rams and Packers.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
