The Bills have signed coach Sean McDermott to a multi-year extension. McDermott has gone 25-23 in his first three years with the Bills, making the postseason twice. He and the Bills will try to build off a 10-6 finish in 2019, which was the franchise’s best record since 1999
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
