The Bills had not made the playoffs since 1999 when they advanced to the Wild Card round after Sean McDermott’s first season as head coach in 2017. McDermott has the team on the doorstep of another trip to the postseason and one win in the final three weeks of the season will officially book that
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -110 |
| Los Angeles Chargers | -110 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Pittsburgh Steelers vs Minnesota Vikings | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Steelers | +110 |
| Minnesota Vikings | -130 |
| Cleveland Browns vs Minnesota Vikings | |
| Type: Point Spread - Status: OPEN | |
| Cleveland Browns | -110 |
| Minnesota Vikings | -110 |
| New York Jets vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| New York Jets | +230 |
| Denver Broncos | -280 |
| Jacksonville Jaguars vs Los Angeles Rams | |
| Type: Moneyline - Status: OPEN | |
| Jacksonville Jaguars | +175 |
| Los Angeles Rams | -210 |
| Indianapolis Colts vs Atlanta Falcons | |
| Type: Moneyline - Status: OPEN | |
| Indianapolis Colts | +105 |
| Atlanta Falcons | -125 |
| Green Bay Packers vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Green Bay Packers | +100 |
| Philadelphia Eagles | -120 |
| Miami Dolphins vs Washington Commanders | |
| Type: Moneyline - Status: OPEN | |
| Miami Dolphins | +120 |
| Washington Commanders | -140 |
| Philadelphia Eagles vs Chicago Bears | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Eagles | -340 |
| Chicago Bears | +270 |
| Washington Commanders vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Washington Commanders | +100 |
| Philadelphia Eagles | -120 |
| Chicago Bears vs Green Bay Packers | |
| Type: Moneyline - Status: OPEN | |
| Chicago Bears | +100 |
| Green Bay Packers | -120 |
| Kansas City Chiefs vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Chiefs | -210 |
| Denver Broncos | +175 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
