The Bills had not made the playoffs since 1999 when they advanced to the Wild Card round after Sean McDermott’s first season as head coach in 2017. McDermott has the team on the doorstep of another trip to the postseason and one win in the final three weeks of the season will officially book that
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
