The Bills lost rookie quarterback Josh Allen to an elbow injury. Nathan Peterman came on in relief and threw one touchdown and two interceptions, including a pick-six, in Buffalo’s loss to Houston.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
