Here are the most significant NFL injuries in Week 14: Thursday Alvin Kamara, RB, New Orleans Saints: New Orleans lost half of its dynamic 1-2 punch in the backfield when Kamara took a shot to the helmet and staggered off with a concussion during the first offensive possession against the Falcons.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |