After surrendering a five-point lead in the fourth quarter, the Bills’ offense responded with back-to-back scoring drives, including a 21-second drive that ended in a 45-yard field goal to beat the Lions on Thanksgiving Day.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
