Baker Mayfield was injured with seven seconds remaining in the first half, hitting his right hand on the helmet of Bud Dupree on his follow-through. Garrett Gilbert replaced Mayfield for the final two plays of the half as Mayfield left for the locker room holding his hand. Mayfield went 10-of-17 for
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
