Day: Saturday, October 19Time: 3:00 PM CSTLocation: Houchens Industries–L. T. Smith StadiumNetwork: ESPN+Betting line: WKU -9.0 | O/U: 48.0History: The Hilltoppers and 49ers are tied 1-1. Last year, Charlotte decisively defeated WKU 40-14.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
