The New Orleans Saints-Minnesota Vikings opener on “Monday Night Football” looked like a curious scheduling choice, then it looked brilliant when Adrian Peterson signed with the Saints (conspiracy theorists unite!). Peterson took note of the Week 1 opponent when he signed with the Saints, his second NFL team after 10 Hall-of-Fame seasons with the Vikings. Adrian Peterson will play his former team, the Vikings, in Week 1.
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -110 |
| Los Angeles Chargers | -110 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Pittsburgh Steelers vs Minnesota Vikings | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Steelers | +110 |
| Minnesota Vikings | -130 |
| Cleveland Browns vs Minnesota Vikings | |
| Type: Point Spread - Status: OPEN | |
| Cleveland Browns | -110 |
| Minnesota Vikings | -110 |
| Philadelphia Eagles vs Chicago Bears | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Eagles | -340 |
| Chicago Bears | +270 |
| Washington Commanders vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Washington Commanders | +100 |
| Philadelphia Eagles | -120 |
| Chicago Bears vs Green Bay Packers | |
| Type: Moneyline - Status: OPEN | |
| Chicago Bears | +100 |
| Green Bay Packers | -120 |
| Kansas City Chiefs vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Chiefs | -200 |
| Denver Broncos | +170 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
