The 49ers clinched the NFC’s No. 1 overall seed after beating the Commanders and getting help from the Cardinals and Cowboys, who beat the Eagles and Lions, respectively.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
