The 49ers Week 16 game at the Arizona Cardinals will be played Saturday, Dec. 26, at 1:30 p.m., the NFL announced on Monday.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
