Jimmy Garoppolo completed only three of seven passes on the opening possession, and Matt Breida and Tevin Coleman combined for only 4 yards on four carries. Yet, the 49ers have a 3-0 lead after one possession. New kicker Chase McLaughlin, filling in for the injured Robbie Gould, was good on a 43-yard
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
