Eric Reid and Reuben Foster were among 49ers players to state their disappointment with 49ers fans for cheering while quarterback C.J. Beathard was still on the ground after a hard hit Sunday. The injury led to Jimmy Garoppolo’s debut with the team.
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
