49ers RB Christian McCaffrey, playing in just his fourth game since returning from Achilles tendinitis, suffered a PCL injury Sunday night in Buffalo that coach Kyle Shanahan described as potentially season-ending.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |