For the second time this year, the 49ers have a pair of back-to-back games that start at 1:00 p.m. ET. For the second time this year, the 49ers spent the week between those games away from home. After Week One at Tampa, they stayed in Ohio before beating the Bengals in Cincinnati. After Week Thirteen
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
