With a stunning, come-from-behind win against the Lions in Sunday’s NFC Championship Game — a game in which they trailed by 17 points — the 49ers are returning to the Super Bowl and looking to atone for their loss to the Chiefs in 2020.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |