SANTA CLARA – Four of the next six weeks, the 49ers will be featured on prime time, available to national television audiences. The potential star power of Jimmy Garoppolo will not be on display, as Garoppolo underwent season-ending surgery this week to repair a torn ACL in his left knee.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |