The 49ers have had to make a replacement on the defensive line, and brought back a familiar face. The team announced that defensive end Ronald Blair was placed on injured reserve after injuring his knee Monday, and that he was replaced on the roster by Damontre Moore. Moore was with the 49ers this offseason
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
