The 49ers have had to make a replacement on the defensive line, and brought back a familiar face. The team announced that defensive end Ronald Blair was placed on injured reserve after injuring his knee Monday, and that he was replaced on the roster by Damontre Moore. Moore was with the 49ers this offseason
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
