We’re going to look at departures from each position prior to Week 1 of the 2018 season and see how they fared after leaving the San Francisco 49ers. Some players went on to better careers, while others may be out of the league. We won’t be highlighting every transaction, just some notable ones
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |