The universal preseason favorite has been dethroned as the No. 1 Super Bowl favorite, with the Pittsburgh Steelers jumping the New England Patriots for the top spot. New England is one dominant performance away from retaking favorite bragging rights, but the Steelers bounced back from a brutal Week 3
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
