First it was Giannis Antetokounmpo and the Bucks, unable to call upon what was one of the best defenses in the league. Then came LeBron James and the Lakers, clanging 3-pointers off the rim to provide a steady sound in a mostly empty gym. Milwaukee and Los Angeles lost their playoff openers, the first time both conference No. 1 seeds have been beaten by the No. 8s to start their postseasons since 2003.
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| Houston Rockets vs Golden State Warriors | |
| Type: Total - Status: OPEN | |
| Under - 1H | -110 |
| Over - 1H | -110 |
| New York Knicks vs Detroit Pistons | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Denver Nuggets vs L.A. Clippers | |
| Type: Moneyline - Status: OPEN | |
| Denver Nuggets - 1H | +100 |
| L.A. Clippers - 1H | -120 |
| Indiana Pacers vs Milwaukee Bucks | |
| Type: Point Spread - Status: OPEN | |
| Indiana Pacers | -110 |
| Milwaukee Bucks | -110 |
| Oklahoma City Thunder vs Memphis Grizzlies | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Los Angeles Lakers vs Minnesota Timberwolves | |
| Type: Point Spread - Status: OPEN | |
| Los Angeles Lakers - 1H | -105 |
| Minnesota Timberwolves - 1H | -115 |
| Boston Celtics vs Orlando Magic | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |