The Detroit Pistons went the expected route by selecting Oklahoma State point guard Cade Cunningham first overall in the 2021 NBA draft.
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| Cleveland Cavaliers vs Miami Heat | |
| Type: Moneyline - Status: OPEN | |
| Cleveland Cavaliers - 1H | -430 |
| Miami Heat - 1H | +320 |
| Houston Rockets vs Golden State Warriors | |
| Type: Total - Status: OPEN | |
| Under - 1H | -110 |
| Over - 1H | -110 |
| New York Knicks vs Detroit Pistons | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Denver Nuggets vs L.A. Clippers | |
| Type: Moneyline - Status: OPEN | |
| Denver Nuggets - 1H | +100 |
| L.A. Clippers - 1H | -120 |
| Indiana Pacers vs Milwaukee Bucks | |
| Type: Point Spread - Status: OPEN | |
| Indiana Pacers | -110 |
| Milwaukee Bucks | -110 |
| Oklahoma City Thunder vs Memphis Grizzlies | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Los Angeles Lakers vs Minnesota Timberwolves | |
| Type: Point Spread - Status: OPEN | |
| Los Angeles Lakers - 1H | -105 |
| Minnesota Timberwolves - 1H | -115 |
