For better or much much worse, a record number of clubs could reach the century mark in the win — and loss — column this season.
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| Chiba Lotte Marines vs Tohoku Rakuten Golden Eagles | |
| Type: Runline - Status: OPEN | |
| Chiba Lotte Marines | +130 |
| Tohoku Rakuten Golden Eagles | -170 |
| Tokyo Yakult Swallows vs Hiroshima Toyo Carp | |
| Type: Runline - Status: OPEN | |
| Tokyo Yakult Swallows | +125 |
| Hiroshima Toyo Carp | -165 |
| Yomiuri Giants vs Hanshin Tigers | |
| Type: Moneyline - Status: OPEN | |
| Yomiuri Giants | -150 |
| Hanshin Tigers | +115 |
| Saitama Seibu Lions vs Fukuoka SoftBank Hawks | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Orix Buffaloes vs Hokkaido Nippon-Ham Fighters | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Washington Nationals vs Cleveland Guardians | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | +100 |
| New York Yankees vs San Diego Padres | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
| Atlanta Braves vs Cincinnati Reds | |
| Type: Runline - Status: OPEN | |
| Atlanta Braves - 1H | -105 |
| Cincinnati Reds - 1H | -125 |
| Milwaukee Brewers vs Houston Astros | |
| Type: Moneyline - Status: OPEN | |
| Milwaukee Brewers - 1I | -125 |
| Houston Astros - 1I | -105 |
| Kansas City Royals vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals - 1H | -215 |
| Chicago White Sox - 1H | +160 |
| Chicago Cubs vs San Francisco Giants | |
| Type: Moneyline - Status: OPEN | |
| San Francisco Giants | +123 |
| Chicago Cubs | -147 |
| St. Louis Cardinals vs Pittsburgh Pirates | |
| Type: Total - Status: OPEN | |
| Under - 1H | -110 |
| Over - 1H | -120 |
| Athletics vs Seattle Mariners | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
