Pitchers are generally ahead of hitters at this point of the spring, but for Brett Gardner and Chase Headley, taking their first at-bats of the year against Dellin Betances and Masahiro Tanaka proved to be an especially unfair matchup.
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| Acereros de Monclova vs Tecolotes de los Dos Laredos | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -120 |
| Piratas de Campeche vs Tigres de Quintana Roo | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -130 |
| El Aguila de Veracruz vs Pericos de Puebla | |
| Type: Moneyline - Status: OPEN | |
| El Aguila de Veracruz | -155 |
| Pericos de Puebla | +110 |
| Olmecas de Tabasco vs Guerreros de Oaxaca | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -120 |
| Toros de Tijuana vs Rieleros de Aguascalientes | |
| Type: Runline - Status: OPEN | |
| Toros de Tijuana | +105 |
| Rieleros de Aguascalientes | -150 |
| Colorado Rockies vs Washington Nationals | |
| Type: Total - Status: OPEN | |
| Under - 1I | -215 |
| Over - 1I | +160 |
| Algodoneros del Unión Laguna vs Dorados de Chihuahua | |
| Type: Runline - Status: OPEN | |
| Algodoneros del Unión Laguna | -135 |
| Dorados de Chihuahua | -105 |
| Boston Red Sox vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Over - 1H | -130 |
| Under - 1H | +100 |
| Cleveland Guardians vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1I | -110 |
| Cleveland Guardians - 1I | -120 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -115 |
| Cincinnati Reds - 1I | -115 |
| New York Mets vs Philadelphia Phillies | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
| Atlanta Braves vs St. Louis Cardinals | |
| Type: Total - Status: OPEN | |
| Over | +100 |
| Under | -120 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| San Francisco Giants - 1H | -105 |
| Milwaukee Brewers - 1H | -125 |
