Trey Mancini returned this year after missing all of the 2020 season following a Stage 3 colon cancer diagnosis.
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| Bowling Green vs Northern Illinois | |
| Type: Moneyline - Status: OPEN | |
| Bowling Green | -160 |
| Northern Illinois | +120 |
| Prairie View A&M vs Alabama State | |
| Type: Runline - Status: OPEN | |
| Prairie View A&M | -105 |
| Alabama State | -125 |
| Dayton vs Saint Bonaventure | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Saint Joseph's vs Rhode Island | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Western Kentucky vs Jacksonville State | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Chicago Cubs vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Chicago Cubs - 1I | -180 |
| Chicago White Sox - 1I | +135 |
| Pittsburgh Panthers vs Clemson (#15) | |
| Type: Runline - Status: OPEN | |
| Pittsburgh Panthers | -120 |
| Clemson (#15) | -110 |
| Ohio State vs Illinois | |
| Type: Runline - Status: OPEN | |
| Ohio State | -110 |
| Illinois | -120 |
| Old Dominion vs Coastal Carolina (#11) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Virginia Tech vs Virginia | |
| Type: Moneyline - Status: OPEN | |
| Virginia Tech | +100 |
| Virginia | -130 |
| Lipscomb vs Austin Peay | |
| Type: Runline - Status: OPEN | |
| Lipscomb | -110 |
| Austin Peay | -120 |
| San Francisco vs Utah Valley | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Georgetown vs Creighton | |
| Type: Moneyline - Status: OPEN | |
| Georgetown | +165 |
| Creighton | -220 |
| Columbia vs Penn | |
| Type: Moneyline - Status: OPEN | |
| Columbia | -165 |
| Penn | +125 |
| Purdue vs Nebraska | |
| Type: Runline - Status: OPEN | |
| Purdue | -145 |
| Nebraska | +110 |
| Liberty vs Dallas Baptist (#24) | |
| Type: Moneyline - Status: OPEN | |
| Liberty | +200 |
| Dallas Baptist (#24) | -275 |
| New Mexico vs Fresno State | |
| Type: Runline - Status: OPEN | |
| New Mexico | -115 |
| Fresno State | -115 |
| Piratas de Campeche vs Conspiradores de Queretaro | |
| Type: Runline - Status: SUSPENDED | |
| Piratas de Campeche | |
| Conspiradores de Queretaro | |
| Charros de Jalisco vs Dorados de Chihuahua | |
| Type: Moneyline - Status: SUSPENDED | |
| Charros de Jalisco | |
| Dorados de Chihuahua | |
| Toros de Tijuana vs Generales De Durango | |
| Type: Runline - Status: SUSPENDED | |
| Toros de Tijuana | |
| Generales De Durango | |
| Bravos de Leon vs Mexico | |
| Type: Total - Status: SUSPENDED | |
| Under | |
| Over | |
| Tigres de Quintana Roo vs Leones de Yucatan | |
| Type: Moneyline - Status: SUSPENDED | |
| Tigres de Quintana Roo | |
| Leones de Yucatan | |
| Saraperos de Saltillo vs Algodoneros del Unión Laguna | |
| Type: Total - Status: SUSPENDED | |
| Under | |
| Over | |
| Illinois Chicago vs Belmont | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| West Virginia (#16) vs Kansas | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Cincinnati vs Kansas State | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati | -110 |
| Kansas State | -120 |
| Central Florida vs Baylor | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Duke (#20) vs Georgia Tech | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Georgia (#10) vs Texas A&M | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Louisville (#21) vs Wake Forest | |
| Type: Runline - Status: OPEN | |
| Louisville (#21) | -130 |
| Wake Forest | +100 |
| Michigan vs Indiana | |
| Type: Runline - Status: OPEN | |
| Michigan | -165 |
| Indiana | +125 |
| NC State (#13) vs Stanford | |
| Type: Moneyline - Status: OPEN | |
| NC State (#13) | -360 |
| Stanford | +250 |
| Marshall vs Georgia Southern | |
| Type: Moneyline - Status: OPEN | |
| Marshall | -135 |
| Georgia Southern | +105 |
| Maryland vs Rutgers | |
| Type: Runline - Status: SUSPENDED | |
| Maryland | |
| Rutgers | |
| Florida (#23) vs Alabama (#18) | |
| Type: Runline - Status: OPEN | |
| Florida (#23) | -115 |
| Alabama (#18) | -115 |
| Cincinnati Reds vs Cleveland Guardians | |
| Type: Runline - Status: OPEN | |
| Cincinnati Reds - 1H | -145 |
| Cleveland Guardians - 1H | +110 |
| Philadelphia Phillies vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Phillies - 1H | -230 |
| Pittsburgh Pirates - 1H | +170 |
| Miami Florida vs Notre Dame | |
| Type: Moneyline - Status: OPEN | |
| Miami Florida | -230 |
| Notre Dame | +170 |
| Florida State (#2) vs North Carolina (#4) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Oklahoma State vs Arizona State | |
| Type: Moneyline - Status: OPEN | |
| Oklahoma State | -110 |
| Arizona State | -120 |
| Missouri vs Mississippi State | |
| Type: Runline - Status: OPEN | |
| Missouri | -110 |
| Mississippi State | -120 |
| South Carolina vs LSU (#1) | |
| Type: Runline - Status: OPEN | |
| South Carolina | -115 |
| LSU (#1) | -115 |
| Texas State vs James Madison | |
| Type: Moneyline - Status: OPEN | |
| Texas State | -200 |
| James Madison | +150 |
| UL Lafayette vs Arkansas State | |
| Type: Runline - Status: OPEN | |
| UL Lafayette | +105 |
| Arkansas State | -135 |
| Troy (#22) vs Southern Mississippi (#19) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Vanderbilt (#9) vs Kentucky | |
| Type: Runline - Status: OPEN | |
| Vanderbilt (#9) | -120 |
| Kentucky | -110 |
| UL Monroe vs South Alabama | |
| Type: Runline - Status: OPEN | |
| UL Monroe | -105 |
| South Alabama | -125 |
| Mississippi vs Auburn (#6) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Baltimore Orioles vs Washington Nationals | |
| Type: Runline - Status: OPEN | |
| Washington Nationals - 1H | +115 |
| Baltimore Orioles - 1H | -150 |
| New York Yankees vs New York Mets | |
| Type: Total - Status: OPEN | |
| Over | -120 |
| Under | +100 |
| Toronto Blue Jays vs Detroit Tigers | |
| Type: Total - Status: OPEN | |
| Under - 1H | -110 |
| Over - 1H | -120 |
| Boston Red Sox vs Atlanta Braves | |
| Type: Moneyline - Status: OPEN | |
| Boston Red Sox | -114 |
| Atlanta Braves | -106 |
| Miami Marlins vs Tampa Bay Rays | |
| Type: Total - Status: OPEN | |
| Over - 1H | -105 |
| Under - 1H | -125 |
| Houston vs Arizona Wildcats | |
| Type: Runline - Status: OPEN | |
| Houston | -135 |
| Arizona Wildcats | +105 |
| Arkansas (#8) vs Tennessee (#17) | |
| Type: Moneyline - Status: OPEN | |
| Arkansas (#8) | -115 |
| Tennessee (#17) | -115 |
| Oklahoma vs Texas (#3) | |
| Type: Moneyline - Status: OPEN | |
| Oklahoma | +110 |
| Texas (#3) | -145 |
| Kansas City Royals vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1I | +115 |
| Kansas City Royals - 1I | -150 |
| BYU vs Texas Tech | |
| Type: Runline - Status: OPEN | |
| BYU | +115 |
| Texas Tech | -150 |
| Utah vs TCU | |
| Type: Runline - Status: OPEN | |
| Utah | -110 |
| TCU | -120 |
| Texas Rangers vs Houston Astros | |
| Type: Total - Status: OPEN | |
| Over - 1I | +225 |
| Under - 1I | -310 |
| Milwaukee Brewers vs Minnesota Twins | |
| Type: Moneyline - Status: OPEN | |
| Minnesota Twins - 1H | -115 |
| Milwaukee Brewers - 1H | -115 |
| Oregon State (#7) vs Long Beach State | |
| Type: Moneyline - Status: OPEN | |
| Oregon State (#7) | -575 |
| Long Beach State | +360 |
| UC Irvine (#12) vs CS Fullerton | |
| Type: Moneyline - Status: OPEN | |
| UC Irvine (#12) | -300 |
| CS Fullerton | +215 |
| California vs Boston College | |
| Type: Moneyline - Status: OPEN | |
| California | -130 |
| Boston College | +100 |
| Washington vs USC | |
| Type: Runline - Status: SUSPENDED | |
| Washington | |
| USC | |
| Arizona Diamondbacks vs Colorado Rockies | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks - 1H | -185 |
| Colorado Rockies - 1H | +140 |
| San Diego Padres vs Seattle Mariners | |
| Type: Moneyline - Status: OPEN | |
| San Diego Padres - 1H | -170 |
| Seattle Mariners - 1H | +130 |
| Los Angeles Dodgers vs Los Angeles Angels | |
| Type: Total - Status: OPEN | |
| Over - 1I | +185 |
| Under - 1I | -250 |
| San Francisco Giants vs Athletics | |
| Type: Runline - Status: SUSPENDED | |
| Athletics - 1I | |
| San Francisco Giants - 1I | |
