Pirates right-handed pitcher Mitch Keller will start on Opening Day against the Reds, manager Derek Shelton said.
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| Miami Marlins vs Colorado Rockies | |
| Type: Runline - Status: OPEN | |
| Miami Marlins - 1H | -120 |
| Colorado Rockies - 1H | -110 |
| Pittsburgh Pirates vs Houston Astros | |
| Type: Runline - Status: OPEN | |
| Pittsburgh Pirates - 1H | -120 |
| Houston Astros - 1H | -110 |
| Washington Nationals vs Chicago Cubs | |
| Type: Moneyline - Status: OPEN | |
| Washington Nationals - 1H | +120 |
| Chicago Cubs - 1H | -160 |
| New York Yankees vs Cleveland Guardians | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Toronto Blue Jays vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Toronto Blue Jays | +120 |
| Philadelphia Phillies | -143 |
| Boston Red Sox vs Los Angeles Angels | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Cincinnati Reds vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| Cincinnati Reds - 1H | +110 |
| Milwaukee Brewers - 1H | -145 |
| Atlanta Braves vs Arizona Diamondbacks | |
| Type: Moneyline - Status: OPEN | |
| Atlanta Braves | -144 |
| Arizona Diamondbacks | +121 |
| Tampa Bay Rays vs Texas Rangers | |
| Type: Runline - Status: OPEN | |
| Tampa Bay Rays - 1H | +100 |
| Texas Rangers - 1H | -130 |
| St. Louis Cardinals vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1I | -145 |
| Kansas City Royals - 1I | +110 |
| Seattle Mariners vs Baltimore Orioles | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| San Francisco Giants vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| San Francisco Giants | -148 |
| San Diego Padres | +124 |
| Athletics vs Minnesota Twins | |
| Type: Runline - Status: OPEN | |
| Athletics | -105 |
| Minnesota Twins | -115 |
| Los Angeles Dodgers vs New York Mets | |
| Type: Runline - Status: OPEN | |
| Los Angeles Dodgers | +145 |
| New York Mets | -170 |
