The baseball that Jose Ramirez deposited in the basket above the ivy-covered wall in right at Wrigley Field was just the start. The Indians have plenty of bad memories when it comes to the Cubs, but Tuesday night did not stir any flashbacks. Ramirez saw to that in the third inning, when he launched a three-run home run off Cubs righty Tyler Chatwood to ignite a 10-1 rout for the Tribe in its first trip back to the Friendly Confines since the 2016 World Series. There is no rewriting that history, but Cleveland turned in a much more memorable box score this time around.
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| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| Cleveland Guardians - 1H | -125 |
| Milwaukee Brewers - 1H | -105 |
| Home Total Runs vs Away Total Runs | |
| Type: Moneyline - Status: OPEN | |
| Home Total Runs | -240 |
| Away Total Runs | +195 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Runline - Status: OPEN | |
| Detroit Tigers - 1H | -145 |
| Boston Red Sox - 1H | +110 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1I | +135 |
| Philadelphia Phillies - 1I | -180 |
| New York Mets vs Pittsburgh Pirates | |
| Type: Runline - Status: OPEN | |
| New York Mets | +135 |
| Pittsburgh Pirates | -160 |
| Atlanta Braves vs Washington Nationals | |
| Type: Runline - Status: OPEN | |
| Atlanta Braves | +115 |
| Washington Nationals | -135 |
| Chicago Cubs vs Miami Marlins | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Texas Rangers vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over - 1H | -130 |
| Under - 1H | +100 |
| Houston Astros vs Kansas City Royals | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Algodoneros del Unión Laguna vs Toros de Tijuana | |
| Type: Moneyline - Status: OPEN | |
| Algodoneros del Unión Laguna | -115 |
| Toros de Tijuana | -125 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Runline - Status: OPEN | |
| San Diego Padres - 1H | -130 |
| Los Angeles Angels - 1H | +100 |
| Seattle Mariners vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| Seattle Mariners - 1H | +105 |
| New York Yankees - 1H | -135 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks | +145 |
| San Francisco Giants | -170 |
| Hokkaido Nippon-Ham Fighters vs Orix Buffaloes | |
| Type: Moneyline - Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | -145 |
| Orix Buffaloes | +110 |
| Tohoku Rakuten Golden Eagles vs Chiba Lotte Marines | |
| Type: Moneyline - Status: OPEN | |
| Tohoku Rakuten Golden Eagles | -120 |
| Chiba Lotte Marines | -110 |
| Fukuoka SoftBank Hawks vs Saitama Seibu Lions | |
| Type: Moneyline - Status: OPEN | |
| Fukuoka SoftBank Hawks | -230 |
| Saitama Seibu Lions | +175 |
| Chunichi Dragons vs Tokyo Yakult Swallows | |
| Type: Moneyline - Status: OPEN | |
| Chunichi Dragons | -110 |
| Tokyo Yakult Swallows | -120 |
| Hiroshima Toyo Carp vs Yomiuri Giants | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Yokohama DeNa BayStars vs Hanshin Tigers | |
| Type: Moneyline - Status: OPEN | |
| Yokohama DeNa BayStars | +105 |
| Hanshin Tigers | -135 |
| Hanwha Eagles vs Doosan Bears | |
| Type: Runline - Status: OPEN | |
| Hanwha Eagles | -105 |
| Doosan Bears | -125 |
| Kia Tigers vs Lotte Giants | |
| Type: Moneyline - Status: OPEN | |
| Kia Tigers | +105 |
| Lotte Giants | -135 |
| LG Twins vs Kiwoom Heroes | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Samsung Lions vs KT Wiz | |
| Type: Runline - Status: OPEN | |
| Samsung Lions | -130 |
| KT Wiz | +100 |
| SSG Landers vs NC Dinos | |
| Type: Runline - Status: OPEN | |
| SSG Landers | -165 |
| NC Dinos | +125 |
| Fubon Guardians vs TSG Hawks | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Wei Chuan Dragons vs CTBC Brothers | |
| Type: Moneyline - Status: OPEN | |
| Wei Chuan Dragons | -125 |
| CTBC Brothers | -105 |