The baseball that Jose Ramirez deposited in the basket above the ivy-covered wall in right at Wrigley Field was just the start. The Indians have plenty of bad memories when it comes to the Cubs, but Tuesday night did not stir any flashbacks. Ramirez saw to that in the third inning, when he launched a three-run home run off Cubs righty Tyler Chatwood to ignite a 10-1 rout for the Tribe in its first trip back to the Friendly Confines since the 2016 World Series. There is no rewriting that history, but Cleveland turned in a much more memorable box score this time around.
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| Duke vs Murray State | |
| Type: Runline - Status: OPEN | |
| Duke | -105 |
| Murray State | -125 |
| Detroit Tigers vs Chicago Cubs | |
| Type: Moneyline - Status: OPEN | |
| Detroit Tigers - 1I | -120 |
| Chicago Cubs - 1I | -110 |
| LSU (#6) vs West Virginia | |
| Type: Moneyline - Status: OPEN | |
| LSU (#6) | -340 |
| West Virginia | +240 |
| Minnesota Twins vs Toronto Blue Jays | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| St. Louis Cardinals vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1H | +150 |
| Los Angeles Dodgers - 1H | -200 |
| Coastal Carolina (#13) vs Auburn (#4) | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| Pittsburgh Pirates vs Philadelphia Phillies | |
| Type: Total - Status: OPEN | |
| Under | +100 |
| Over | -120 |
| Washington Nationals vs Texas Rangers | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| San Francisco Giants vs Atlanta Braves | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| Chicago White Sox vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Chicago White Sox | +116 |
| Kansas City Royals | -139 |
| Tampa Bay Rays vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Tampa Bay Rays - 1H | +105 |
| Miami Marlins - 1H | -135 |
| Cincinnati Reds vs Arizona Diamondbacks | |
| Type: Total - Status: OPEN | |
| Under | +100 |
| Over | -120 |
| Cleveland Guardians vs Houston Astros | |
| Type: Runline - Status: OPEN | |
| Cleveland Guardians | -175 |
| Houston Astros | +150 |
| Arkansas (#3) vs Tennessee (#14) | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -125 |
| UCLA (#15) vs UTSA | |
| Type: Total - Status: OPEN | |
| Under | +100 |
| Over | -130 |
| New York Yankees vs Boston Red Sox | |
| Type: Total - Status: OPEN | |
| Under - 1I | -360 |
| Over - 1I | +250 |
| Milwaukee Brewers vs San Diego Padres | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Florida State (#9) vs Oregon State (#8) | |
| Type: Moneyline - Status: OPEN | |
| Florida State (#9) | -160 |
| Oregon State (#8) | +120 |
| Los Angeles Angels vs Seattle Mariners | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Angels - 1H | +130 |
| Seattle Mariners - 1H | -170 |
| Colorado Rockies vs New York Mets | |
| Type: Moneyline - Status: OPEN | |
| Colorado Rockies - 1H | +200 |
| New York Mets - 1H | -275 |
| Athletics vs Baltimore Orioles | |
| Type: Runline - Status: OPEN | |
| Athletics - 1H | -145 |
| Baltimore Orioles - 1H | +110 |
| Home Total Runs vs Away Total Runs | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | +105 |
| Hiroshima Toyo Carp vs Saitama Seibu Lions | |
| Type: Runline - Status: OPEN | |
| Hiroshima Toyo Carp | -175 |
| Saitama Seibu Lions | +135 |
| Tokyo Yakult Swallows vs Fukuoka SoftBank Hawks | |
| Type: Moneyline - Status: OPEN | |
| Tokyo Yakult Swallows | +140 |
| Fukuoka SoftBank Hawks | -185 |
| Chunichi Dragons vs Chiba Lotte Marines | |
| Type: Moneyline - Status: OPEN | |
| Chunichi Dragons | -105 |
| Chiba Lotte Marines | -125 |
| Yokohama DeNa BayStars vs Hokkaido Nippon-Ham Fighters | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Hanshin Tigers vs Orix Buffaloes | |
| Type: Moneyline - Status: OPEN | |
| Hanshin Tigers | -155 |
| Orix Buffaloes | +120 |
| Yomiuri Giants vs Tohoku Rakuten Golden Eagles | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Kiwoom Heroes vs LG Twins | |
| Type: Runline - Status: OPEN | |
| Kiwoom Heroes | +105 |
| LG Twins | -135 |
| Doosan Bears vs Lotte Giants | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Kia Tigers vs Hanwha Eagles | |
| Type: Runline - Status: OPEN | |
| Kia Tigers | -145 |
| Hanwha Eagles | +110 |
| KT Wiz vs SSG Landers | |
| Type: Moneyline - Status: OPEN | |
| KT Wiz | -200 |
| SSG Landers | +150 |
| Samsung Lions vs NC Dinos | |
| Type: Runline - Status: OPEN | |
| Samsung Lions | -145 |
| NC Dinos | +110 |