Of the many decisions a manager must make throughout a season, picking an Opening Day starter hardly is the most consequential. After all, every team needs at least five starters — and almost always more — to get through a grueling 162-game schedule.
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| Boston Red Sox vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Over - 1H | -110 |
| Under - 1H | -120 |
| Cleveland Guardians vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1I | -105 |
| Cleveland Guardians - 1I | -125 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -115 |
| Cincinnati Reds - 1I | -115 |
| Detroit Tigers vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| Detroit Tigers - 1H | -165 |
| San Diego Padres - 1H | +125 |
| New York Mets vs Philadelphia Phillies | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
| Atlanta Braves vs St. Louis Cardinals | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -105 |
| Houston Astros vs Toronto Blue Jays | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| San Francisco Giants - 1H | +100 |
| Milwaukee Brewers - 1H | -130 |
