Days before the start of the season, Shohei Ohtani embraced the advice of the Angels’ hitting coach and might have changed baseball history.
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| Shandong Blue Whale vs Guangdong Leopard | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -125 |
| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| Cleveland Guardians - 1H | -125 |
| Milwaukee Brewers - 1H | -105 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Runline - Status: SUSPENDED | |
| Boston Red Sox - 1I | |
| Detroit Tigers - 1I | |
| New York Mets vs Pittsburgh Pirates | |
| Type: Runline - Status: OPEN | |
| New York Mets | +165 |
| Pittsburgh Pirates | -195 |
| Atlanta Braves vs Washington Nationals | |
| Type: Runline - Status: OPEN | |
| Atlanta Braves | +120 |
| Washington Nationals | -140 |
| Chicago Cubs vs Miami Marlins | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Texas Rangers vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over - 1H | -105 |
| Under - 1H | -125 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Runline - Status: OPEN | |
| San Diego Padres - 1H | +100 |
| Los Angeles Angels - 1H | -130 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks | -225 |
| San Francisco Giants | +185 |
