Two big swings from Madison Bumgarner were undone by another bullpen meltdown in a wild opener for the San Francisco Giants that looked an awful lot like last season. Chris Owings singled home the winning run and the Arizona Diamondbacks scored twice with two outs in the bottom of the ninth inning off new San Francisco closer Mark Melancon for a 6-5 victory Sunday. Derailed by a dreadful relief corps last year, the Giants started this season the same way – even after trying to fix the problem by bringing in Melancon on a $62 million, four-year contract.
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| Baltimore Orioles vs Minnesota Twins | |
| Type: Runline - Status: OPEN | |
| Minnesota Twins | -200 |
| Baltimore Orioles | +170 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Runline - Status: OPEN | |
| Philadelphia Phillies | +115 |
| St. Louis Cardinals | -135 |
| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Total - Status: OPEN | |
| Over - 1H | -115 |
| Under - 1H | -115 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Moneyline - Status: OPEN | |
| Arizona Diamondbacks | -111 |
| San Francisco Giants | -109 |
| Seattle Mariners vs New York Yankees | |
| Type: Total - Status: OPEN | |
| Over - 1H | -115 |
| Under - 1H | -115 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Total - Status: OPEN | |
| Under - 1I | -340 |
| Over - 1I | +240 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Total - Status: OPEN | |
| Under | +100 |
| Over | -120 |
| Toronto Blue Jays vs Tampa Bay Rays | |
| Type: Total - Status: OPEN | |
| Over - 1H | -105 |
| Under - 1H | -125 |
| New York Mets vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Pirates - 1H | +175 |
| New York Mets - 1H | -240 |
| Cincinnati Reds vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati Reds | -230 |
| Chicago White Sox | +190 |
| Atlanta Braves vs Washington Nationals | |
| Type: Moneyline - Status: OPEN | |
| Atlanta Braves - 1I | -160 |
| Washington Nationals - 1I | +120 |
| Chicago Cubs vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Chicago Cubs - 1H | +100 |
| Miami Marlins - 1H | -130 |
| Texas Rangers vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over | -105 |
| Under | -115 |
| Houston Astros vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals | +115 |
| Houston Astros | -138 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Total - Status: OPEN | |
| Over - 1I | +210 |
| Under - 1I | -290 |
| Los Angeles Dodgers vs Athletics | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
