Major League Baseball will open the 2022 season on March 31 and will try for the fourth time to have every team play its first game on the same day for the first time since 1968.
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| Long Beach State vs USC | |
| Type: Moneyline - Status: OPEN | |
| Long Beach State | +150 |
| USC | -200 |
| UC Irvine (#12) vs UCLA (#15) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Pericos de Puebla vs Piratas de Campeche | |
| Type: Runline - Status: OPEN | |
| Pericos de Puebla | -110 |
| Piratas de Campeche | -130 |
| Tecolotes de los Dos Laredos vs Generales De Durango | |
| Type: Moneyline - Status: OPEN | |
| Tecolotes de los Dos Laredos | -180 |
| Generales De Durango | +125 |
| Nevada vs Sacramento State | |
| Type: Runline - Status: OPEN | |
| Nevada | +100 |
| Sacramento State | -130 |
| Guerreros de Oaxaca vs Conspiradores de Queretaro | |
| Type: Moneyline - Status: OPEN | |
| Guerreros de Oaxaca | -135 |
| Conspiradores de Queretaro | -105 |
| Olmecas de Tabasco vs Leones de Yucatan | |
| Type: Moneyline - Status: OPEN | |
| Olmecas de Tabasco | -170 |
| Leones de Yucatan | +120 |
| Los Angeles Angels vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Angels | -183 |
| Pittsburgh Pirates | +151 |
| Arizona Diamondbacks vs Tampa Bay Rays | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1I | +120 |
| Arizona Diamondbacks - 1I | -160 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Moneyline - Status: OPEN | |
| San Francisco Giants - 1H | -150 |
| Milwaukee Brewers - 1H | +115 |
| Grand Canyon vs Arizona State | |
| Type: Runline - Status: OPEN | |
| Grand Canyon | -110 |
| Arizona State | -120 |
| Charros de Jalisco vs Algodoneros del Unión Laguna | |
| Type: Runline - Status: OPEN | |
| Charros de Jalisco | -140 |
| Algodoneros del Unión Laguna | +100 |
| Rieleros de Aguascalientes vs Dorados de Chihuahua | |
| Type: Runline - Status: OPEN | |
| Rieleros de Aguascalientes | +130 |
| Dorados de Chihuahua | -185 |
| Saraperos de Saltillo vs Acereros de Monclova | |
| Type: Moneyline - Status: OPEN | |
| Saraperos de Saltillo | -120 |
| Acereros de Monclova | -120 |
| Bravos de Leon vs El Aguila de Veracruz | |
| Type: Moneyline - Status: OPEN | |
| Bravos de Leon | +110 |
| El Aguila de Veracruz | -155 |
| Athletics vs Texas Rangers | |
| Type: Runline - Status: OPEN | |
| Athletics - 1H | -110 |
| Texas Rangers - 1H | -120 |
| Toros de Tijuana vs Sultanes de Monterrey | |
| Type: Runline - Status: OPEN | |
| Sultanes de Monterrey | -225 |
| Toros de Tijuana | +155 |
| Yokohama DeNa BayStars vs Hanshin Tigers | |
| Type: Moneyline - Status: OPEN | |
| Yokohama DeNa BayStars | -135 |
| Hanshin Tigers | +105 |
| Chiba Lotte Marines vs Saitama Seibu Lions | |
| Type: Moneyline - Status: OPEN | |
| Chiba Lotte Marines | -190 |
| Saitama Seibu Lions | +145 |
| Fukuoka SoftBank Hawks vs Orix Buffaloes | |
| Type: Runline - Status: OPEN | |
| Fukuoka SoftBank Hawks | +200 |
| Orix Buffaloes | -275 |
| Hokkaido Nippon-Ham Fighters vs Tohoku Rakuten Golden Eagles | |
| Type: Runline - Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | +185 |
| Tohoku Rakuten Golden Eagles | -250 |
| Hiroshima Toyo Carp vs Tokyo Yakult Swallows | |
| Type: Moneyline - Status: OPEN | |
| Hiroshima Toyo Carp | -165 |
| Tokyo Yakult Swallows | +125 |
| Yomiuri Giants vs Chunichi Dragons | |
| Type: Runline - Status: OPEN | |
| Yomiuri Giants | +125 |
| Chunichi Dragons | -165 |
| Kiwoom Heroes vs Doosan Bears | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -120 |
| KT Wiz vs SSG Landers | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| LG Twins vs NC Dinos | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Lotte Giants vs Hanwha Eagles | |
| Type: Moneyline - Status: OPEN | |
| Lotte Giants | -125 |
| Hanwha Eagles | -105 |
| Samsung Lions vs Kia Tigers | |
| Type: Moneyline - Status: OPEN | |
| Kia Tigers | +115 |
| Samsung Lions | -150 |