With eight teams making it through the wild-card series, we ranked the survivors with an eye on what we learned in Round 1.
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| Baltimore Orioles vs Minnesota Twins | |
| Type: Runline - Status: OPEN | |
| Minnesota Twins | -200 |
| Baltimore Orioles | +170 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Runline - Status: OPEN | |
| Philadelphia Phillies | +115 |
| St. Louis Cardinals | -135 |
| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Total - Status: OPEN | |
| Over - 1H | -120 |
| Under - 1H | -110 |
| Baltimore Orioles vs Minnesota Twins | |
| Type: Moneyline - Status: OPEN | |
| Baltimore Orioles | -126 |
| Minnesota Twins | +106 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Moneyline - Status: OPEN | |
| Arizona Diamondbacks | -110 |
| San Francisco Giants | -110 |
| Seattle Mariners vs New York Yankees | |
| Type: Total - Status: OPEN | |
| Over - 1H | +100 |
| Under - 1H | -130 |
| Indianapolis Indians vs Louisville Bats | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | -105 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Total - Status: OPEN | |
| Under - 1I | -340 |
| Over - 1I | +240 |
| Norfolk Tides vs Jacksonville Jumbo Shrimp | |
| Type: Moneyline - Status: OPEN | |
| Norfolk Tides | +135 |
| Jacksonville Jumbo Shrimp | -180 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Total - Status: OPEN | |
| Under | +100 |
| Over | -120 |
| Gwinnett Stripers vs Charlotte Knights | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Toronto Blue Jays vs Tampa Bay Rays | |
| Type: Total - Status: OPEN | |
| Over - 1H | -105 |
| Under - 1H | -125 |
| New York Mets vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Pirates - 1H | +190 |
| New York Mets - 1H | -260 |
| Cincinnati Reds vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati Reds | -230 |
| Chicago White Sox | +190 |
| Atlanta Braves vs Washington Nationals | |
| Type: Moneyline - Status: OPEN | |
| Atlanta Braves - 1I | -160 |
| Washington Nationals - 1I | +120 |
| Chicago Cubs vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Chicago Cubs - 1H | -120 |
| Miami Marlins - 1H | -110 |
| Texas Rangers vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over | -105 |
| Under | -115 |
| Houston Astros vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals | +106 |
| Houston Astros | -126 |
| Conspiradores de Queretaro vs Tigres de Quintana Roo | |
| Type: Moneyline - Status: OPEN | |
| Conspiradores de Queretaro | -140 |
| Tigres de Quintana Roo | +100 |
| Pericos de Puebla vs Leones de Yucatan | |
| Type: Moneyline - Status: OPEN | |
| Pericos de Puebla | -185 |
| Leones de Yucatan | +130 |
| Sultanes de Monterrey vs Dorados de Chihuahua | |
| Type: Runline - Status: OPEN | |
| Sultanes de Monterrey | +100 |
| Dorados de Chihuahua | -140 |
| Piratas de Campeche vs El Aguila de Veracruz | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -120 |
| Algodoneros del Unión Laguna vs Rieleros de Aguascalientes | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -120 |
| Bravos de Leon vs Guerreros de Oaxaca | |
| Type: Total - Status: OPEN | |
| Under | -130 |
| Over | -110 |
| Saraperos de Saltillo vs Tecolotes de los Dos Laredos | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -120 |
| Generales De Durango vs Charros de Jalisco | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -135 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Total - Status: OPEN | |
| Over - 1I | +210 |
| Under - 1I | -290 |
| Acereros de Monclova vs Toros de Tijuana | |
| Type: Runline - Status: OPEN | |
| Acereros de Monclova | -170 |
| Toros de Tijuana | +120 |
| Los Angeles Dodgers vs Athletics | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |