Spencer Limbach runs through the best MLB DFS Plays on FanDuel and DraftKings for Monday, April 22.
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| Uni-Lions vs Fubon Guardians | |
| Type: Runline - Status: OPEN | |
| Uni-Lions | -125 |
| Fubon Guardians | -105 |
| Tokyo Yakult Swallows vs Yomiuri Giants | |
| Type: Moneyline - Status: OPEN | |
| Tokyo Yakult Swallows | +100 |
| Yomiuri Giants | -130 |
| CTBC Brothers vs TSG Hawks | |
| Type: Runline - Status: OPEN | |
| CTBC Brothers | +165 |
| TSG Hawks | -220 |
| Washington Nationals vs St. Louis Cardinals | |
| Type: Runline - Status: OPEN | |
| St. Louis Cardinals - 1H | -115 |
| Washington Nationals - 1H | -115 |
| Pittsburgh Pirates vs Atlanta Braves | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | +100 |
| New York Mets vs Chicago Cubs | |
| Type: Moneyline - Status: OPEN | |
| Chicago Cubs | +104 |
| New York Mets | -124 |
| Detroit Tigers vs Texas Rangers | |
| Type: Moneyline - Status: OPEN | |
| Detroit Tigers - 1H | -120 |
| Texas Rangers - 1H | -110 |
| Tampa Bay Rays vs Milwaukee Brewers | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1H | -150 |
| Milwaukee Brewers - 1H | +115 |
| Chicago White Sox vs Miami Marlins | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins | -134 |
| Chicago White Sox | +112 |
| Kansas City Royals vs Boston Red Sox | |
| Type: Moneyline - Status: OPEN | |
| Boston Red Sox | +112 |
| Kansas City Royals | -134 |
| Houston Astros vs Cincinnati Reds | |
| Type: Runline - Status: OPEN | |
| Houston Astros - 1H | -105 |
| Cincinnati Reds - 1H | -125 |
| Minnesota Twins vs San Francisco Giants | |
| Type: Moneyline - Status: OPEN | |
| Minnesota Twins - 1I | -135 |
| San Francisco Giants - 1I | +105 |
| Colorado Rockies vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| San Diego Padres - 1I | -190 |
| Colorado Rockies - 1I | +145 |
| Athletics vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1H | -135 |
| Athletics - 1H | +105 |
| Los Angeles Angels vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Baltimore Orioles | -143 |
| Los Angeles Angels | +120 |
| Arizona Diamondbacks vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| Arizona Diamondbacks | -105 |
| Los Angeles Dodgers | -115 |
| Seattle Mariners vs Toronto Blue Jays | |
| Type: Total - Status: OPEN | |
| Over | -120 |
| Under | +100 |
| Cleveland Guardians vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Cleveland Guardians - 1I | +105 |
| Philadelphia Phillies - 1I | -135 |
