Edwin Encarnacion will move to the Cactus League and Chris Sale will get ready in the Grapefruit League. The Astros and Nationals will share a new home called The Ballpark of the Palm Beaches. The World Baseball Classic will intervene once again, and the Cubs will train under the Arizona sun for the first time as World Series champions. The game you loved as a kid and love even more now has a place and a time.
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| North Carolina (#5) vs Arizona | |
| Type: Runline - Status: OPEN | |
| North Carolina (#5) | -115 |
| Arizona | -115 |
| Tampa Bay Rays vs Miami Marlins | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1H | -135 |
| Miami Marlins - 1H | +105 |
| Louisville vs Miami Florida | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Oregon State (#8) vs Florida State (#9) | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Pittsburgh Pirates vs Philadelphia Phillies | |
| Type: Runline - Status: OPEN | |
| Pittsburgh Pirates | -140 |
| Philadelphia Phillies | +120 |
| Washington Nationals vs Texas Rangers | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| New York Yankees vs Boston Red Sox | |
| Type: Total - Status: OPEN | |
| Under - 1H | -130 |
| Over - 1H | +100 |
| Detroit Tigers vs Chicago Cubs | |
| Type: Runline - Status: OPEN | |
| Detroit Tigers - 1H | -125 |
| Chicago Cubs - 1H | -105 |
| Cincinnati Reds vs Arizona Diamondbacks | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati Reds | -103 |
| Arizona Diamondbacks | -117 |
| Cleveland Guardians vs Houston Astros | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Chicago White Sox vs Kansas City Royals | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Milwaukee Brewers vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| Milwaukee Brewers - 1I | -145 |
| San Diego Padres - 1I | +110 |
| Minnesota Twins vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Minnesota Twins | -155 |
| Toronto Blue Jays | +130 |
| St. Louis Cardinals vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1H | -150 |
| Los Angeles Dodgers - 1H | +115 |
| Colorado Rockies vs New York Mets | |
| Type: Runline - Status: OPEN | |
| Colorado Rockies - 1H | +115 |
| New York Mets - 1H | -150 |
| Auburn (#4) vs Coastal Carolina (#13) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Los Angeles Angels vs Seattle Mariners | |
| Type: Runline - Status: OPEN | |
| Los Angeles Angels - 1H | -120 |
| Seattle Mariners - 1H | -110 |
| Athletics vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Athletics - 1H | +105 |
| Baltimore Orioles - 1H | -135 |
| San Francisco Giants vs Atlanta Braves | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Duke vs Murray State | |
| Type: Runline - Status: OPEN | |
| Duke | -130 |
| Murray State | +100 |
| LSU (#6) vs West Virginia | |
| Type: Moneyline - Status: OPEN | |
| LSU (#6) | -330 |
| West Virginia | +235 |
| Arkansas (#3) vs Tennessee (#14) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| UCLA (#15) vs UTSA | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |