The Blue Jays, who haven’t played a game in Toronto since the 2019 season due to Canadian government restrictions during the coronavirus pandemic, will again set up shop in Buffalo after spending the first two months of the 2021 season in Florida.
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| Atlanta Braves vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1H | +130 |
| Atlanta Braves - 1H | -170 |
| Cleveland Guardians vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees | -174 |
| Cleveland Guardians | +143 |
| Detroit Tigers vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| San Diego Padres - 1H | +135 |
| Detroit Tigers - 1H | -180 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Runline - Status: OPEN | |
| Miami Marlins | +175 |
| Cincinnati Reds | -210 |
| New York Mets vs Philadelphia Phillies | |
| Type: Total - Status: OPEN | |
| Over - 1I | +250 |
| Under - 1I | -360 |
| Boston Red Sox vs Seattle Mariners | |
| Type: Runline - Status: OPEN | |
| Seattle Mariners - 1H | -120 |
| Boston Red Sox - 1H | -110 |
| Washington Nationals vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Washington Nationals - 1I | -110 |
| Baltimore Orioles - 1I | -120 |
| Chicago Cubs vs Los Angeles Dodgers | |
| Type: Total - Status: OPEN | |
| Over - 1H | -120 |
| Under - 1H | -110 |
| Minnesota Twins vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Chicago White Sox | +210 |
| Minnesota Twins | -260 |
| Kansas City Royals vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over - 1H | -120 |
| Under - 1H | -110 |
| Houston Astros vs Toronto Blue Jays | |
| Type: Runline - Status: OPEN | |
| Houston Astros - 1H | +115 |
| Toronto Blue Jays - 1H | -150 |
| Los Angeles Angels vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Pirates - 1H | +105 |
| Los Angeles Angels - 1H | -135 |
| Arizona Diamondbacks vs Tampa Bay Rays | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1I | +110 |
| Arizona Diamondbacks - 1I | -145 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| Athletics vs Texas Rangers | |
| Type: Total - Status: OPEN | |
| Under - 1H | -110 |
| Over - 1H | -120 |
| Yokohama DeNa BayStars vs Hanshin Tigers | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| Kiwoom Heroes vs Doosan Bears | |
| Type: Runline - Status: OPEN | |
| Doosan Bears | -110 |
| Kiwoom Heroes | -120 |
| KT Wiz vs SSG Landers | |
| Type: Moneyline - Status: OPEN | |
| KT Wiz | -125 |
| SSG Landers | -105 |
| LG Twins vs NC Dinos | |
| Type: Runline - Status: OPEN | |
| LG Twins | -105 |
| NC Dinos | -125 |
| Lotte Giants vs Hanwha Eagles | |
| Type: Total - Status: OPEN | |
| Over | -125 |
| Under | -105 |
| Samsung Lions vs Kia Tigers | |
| Type: Moneyline - Status: OPEN | |
| Kia Tigers | +150 |
| Samsung Lions | -200 |