Corey Kluber logged 11 strikeouts in earning his career-high 19th win, while becoming the third Indians pitcher to notch 200 K’s this season in the series opener. Jason Kipnis hit his 16th homer for the Tribe off White Sox starter Carlos Rodon, whose streak of six straight quality starts on the road was snapped despite homers by Daniel Palka and Omar Narvaez.
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| Cleveland Guardians vs New York Yankees | |
| Type: Runline - Status: SUSPENDED | |
| New York Yankees - 1I | |
| Cleveland Guardians - 1I | |
| Detroit Tigers vs San Diego Padres | |
| Type: Runline - Status: OPEN | |
| Detroit Tigers | +195 |
| San Diego Padres | -235 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -115 |
| Cincinnati Reds - 1I | -115 |
| Boston Red Sox vs Seattle Mariners | |
| Type: Total - Status: OPEN | |
| Over | -105 |
| Under | -115 |
| Washington Nationals vs Baltimore Orioles | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
| New York Mets vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Phillies | -138 |
| New York Mets | +115 |
| Minnesota Twins vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Chicago Cubs vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Dodgers | -120 |
| Chicago Cubs | +100 |
| Kansas City Royals vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Houston Astros vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Houston Astros - 1H | -110 |
| Toronto Blue Jays - 1H | -120 |
| Los Angeles Angels vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Angels | -195 |
| Pittsburgh Pirates | +160 |
| Arizona Diamondbacks vs Tampa Bay Rays | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1I | +115 |
| Arizona Diamondbacks - 1I | -150 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Moneyline - Status: OPEN | |
| San Francisco Giants - 1H | -145 |
| Milwaukee Brewers - 1H | +110 |
| Athletics vs Texas Rangers | |
| Type: Runline - Status: OPEN | |
| Athletics - 1H | -125 |
| Texas Rangers - 1H | -105 |