The Indians declined 2021 options on first baseman Carlos Santana ($17.5M), relief pitcher Brad Hand ($10M) and outfielder Domingo Santana ($5M) but decided to keep catcher Roberto Perez in the fold.
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| Chicago Cubs vs Miami Marlins | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Texas Rangers vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over - 1H | -120 |
| Under - 1H | -110 |
| Houston Astros vs Kansas City Royals | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Algodoneros del Unión Laguna vs Toros de Tijuana | |
| Type: Moneyline - Status: OPEN | |
| Algodoneros del Unión Laguna | -115 |
| Toros de Tijuana | -125 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Runline - Status: OPEN | |
| San Diego Padres - 1H | -130 |
| Los Angeles Angels - 1H | +100 |
| Seattle Mariners vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| Seattle Mariners - 1H | +105 |
| New York Yankees - 1H | -135 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks | +145 |
| San Francisco Giants | -170 |
| Hokkaido Nippon-Ham Fighters vs Orix Buffaloes | |
| Type: Moneyline - Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | -145 |
| Orix Buffaloes | +110 |
| Tohoku Rakuten Golden Eagles vs Chiba Lotte Marines | |
| Type: Moneyline - Status: OPEN | |
| Tohoku Rakuten Golden Eagles | -115 |
| Chiba Lotte Marines | -115 |
| Fukuoka SoftBank Hawks vs Saitama Seibu Lions | |
| Type: Moneyline - Status: OPEN | |
| Fukuoka SoftBank Hawks | -230 |
| Saitama Seibu Lions | +175 |
| Chunichi Dragons vs Tokyo Yakult Swallows | |
| Type: Moneyline - Status: OPEN | |
| Chunichi Dragons | -110 |
| Tokyo Yakult Swallows | -120 |
| Hiroshima Toyo Carp vs Yomiuri Giants | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Yokohama DeNa BayStars vs Hanshin Tigers | |
| Type: Moneyline - Status: OPEN | |
| Yokohama DeNa BayStars | +105 |
| Hanshin Tigers | -135 |
| Hanwha Eagles vs Doosan Bears | |
| Type: Runline - Status: OPEN | |
| Hanwha Eagles | -110 |
| Doosan Bears | -120 |
| Kia Tigers vs Lotte Giants | |
| Type: Moneyline - Status: OPEN | |
| Kia Tigers | +110 |
| Lotte Giants | -145 |
| LG Twins vs Kiwoom Heroes | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Samsung Lions vs KT Wiz | |
| Type: Runline - Status: OPEN | |
| Samsung Lions | -130 |
| KT Wiz | +100 |
| SSG Landers vs NC Dinos | |
| Type: Runline - Status: OPEN | |
| SSG Landers | -165 |
| NC Dinos | +125 |
| Fubon Guardians vs TSG Hawks | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| Wei Chuan Dragons vs CTBC Brothers | |
| Type: Moneyline - Status: OPEN | |
| Wei Chuan Dragons | -125 |
| CTBC Brothers | -105 |
