Once again, the Cleveland Indians are minus a significant piece. Second baseman Jason Kipnis is likely to miss opening day because of a sore right shoulder, an injury that could cause the AL champions to re-shape their infield for the start of this season. Kipnis has been slowed by inflammation in his shoulder throughout training camp and the Indians are going to shut him down for two weeks to see how it responds.
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| Tianjin Lion vs Shanghai Eagles | |
| Type: Moneyline - Status: OPEN | |
| Tianjin Lion | +345 |
| Shanghai Eagles | -470 |
| Henan Wolves vs Beijing Tiger | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Tianjin University of Sport vs Shandong Blue Whale | |
| Type: Moneyline - Status: OPEN | |
| Tianjin University of Sport | +235 |
| Shandong Blue Whale | -300 |
| Hokkaido Nippon-Ham Fighters vs Hanshin Tigers | |
| Type: Moneyline - Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | +105 |
| Hanshin Tigers | -135 |
| Saitama Seibu Lions vs Tokyo Yakult Swallows | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Chiba Lotte Marines vs Yomiuri Giants | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| Tohoku Rakuten Golden Eagles vs Yokohama DeNa BayStars | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Fukuoka SoftBank Hawks vs Chunichi Dragons | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| Orix Buffaloes vs Hiroshima Toyo Carp | |
| Type: Moneyline - Status: OPEN | |
| Orix Buffaloes | -155 |
| Hiroshima Toyo Carp | +120 |
| Doosan Bears vs Kia Tigers | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | -105 |
| Hanwha Eagles vs KT Wiz | |
| Type: Moneyline - Status: OPEN | |
| Hanwha Eagles | +105 |
| KT Wiz | -135 |
| Lotte Giants vs Kiwoom Heroes | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| NC Dinos vs LG Twins | |
| Type: Moneyline - Status: OPEN | |
| NC Dinos | -110 |
| LG Twins | -120 |
| SSG Landers vs Samsung Lions | |
| Type: Runline - Status: OPEN | |
| SSG Landers | +120 |
| Samsung Lions | -155 |
| Atlanta Braves vs Arizona Diamondbacks | |
| Type: Total - Status: SUSPENDED | |
| Under - 1I | |
| Over - 1I | |
| Chicago White Sox vs Detroit Tigers | |
| Type: Total - Status: OPEN | |
| Under - 1H | -120 |
| Over - 1H | -110 |
| Toronto Blue Jays vs Philadelphia Phillies | |
| Type: Runline - Status: OPEN | |
| Toronto Blue Jays - 1H | -145 |
| Philadelphia Phillies - 1H | +110 |
| Seattle Mariners vs Baltimore Orioles | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| San Francisco Giants vs San Diego Padres | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | +100 |
| Pittsburgh Pirates vs Houston Astros | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| New York Yankees vs Cleveland Guardians | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1H | -260 |
| Cleveland Guardians - 1H | +190 |
| Tampa Bay Rays vs Texas Rangers | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays | -148 |
| Texas Rangers | +124 |
| North Carolina (#5) vs Arizona | |
| Type: Runline - Status: OPEN | |
| North Carolina (#5) | -115 |
| Arizona | -115 |
| Louisville vs Miami Florida | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Oregon State (#8) vs Florida State (#9) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Auburn (#4) vs Coastal Carolina (#13) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Duke vs Murray State | |
| Type: Runline - Status: OPEN | |
| Duke | -130 |
| Murray State | +100 |
| LSU (#6) vs West Virginia | |
| Type: Moneyline - Status: OPEN | |
| LSU (#6) | -330 |
| West Virginia | +235 |
| Arkansas (#3) vs Tennessee (#14) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| UCLA (#15) vs UTSA | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |