Once again, the Cleveland Indians are minus a significant piece. Second baseman Jason Kipnis is likely to miss opening day because of a sore right shoulder, an injury that could cause the AL champions to re-shape their infield for the start of this season. Kipnis has been slowed by inflammation in his shoulder throughout training camp and the Indians are going to shut him down for two weeks to see how it responds.
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| Yokohama DeNa BayStars vs Hanshin Tigers | |
| Type: Runline - Status: OPEN | |
| Yokohama DeNa BayStars | -175 |
| Hanshin Tigers | +135 |
| Chiba Lotte Marines vs Saitama Seibu Lions | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Fukuoka SoftBank Hawks vs Orix Buffaloes | |
| Type: Runline - Status: OPEN | |
| Fukuoka SoftBank Hawks | +115 |
| Orix Buffaloes | -150 |
| Hokkaido Nippon-Ham Fighters vs Tohoku Rakuten Golden Eagles | |
| Type: Moneyline - Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | -185 |
| Tohoku Rakuten Golden Eagles | +140 |
| Yomiuri Giants vs Chunichi Dragons | |
| Type: Runline - Status: OPEN | |
| Yomiuri Giants | +130 |
| Chunichi Dragons | -170 |
| Hiroshima Toyo Carp vs Tokyo Yakult Swallows | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | -105 |
| Kiwoom Heroes vs Doosan Bears | |
| Type: Moneyline - Status: OPEN | |
| Kiwoom Heroes | +110 |
| Doosan Bears | -145 |
| KT Wiz vs SSG Landers | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| LG Twins vs NC Dinos | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -115 |
| Lotte Giants vs Hanwha Eagles | |
| Type: Runline - Status: OPEN | |
| Lotte Giants | +145 |
| Hanwha Eagles | -190 |
| Samsung Lions vs Kia Tigers | |
| Type: Runline - Status: OPEN | |
| Samsung Lions | +125 |
| Kia Tigers | -165 |
| Fubon Guardians vs Wei Chuan Dragons | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -120 |
| Uni-Lions vs CTBC Brothers | |
| Type: Moneyline - Status: OPEN | |
| Uni-Lions | -120 |
| CTBC Brothers | -110 |
| Cleveland Guardians vs New York Yankees | |
| Type: Runline - Status: SUSPENDED | |
| New York Yankees - 1I | |
| Cleveland Guardians - 1I | |
| Detroit Tigers vs San Diego Padres | |
| Type: Runline - Status: OPEN | |
| Detroit Tigers | +195 |
| San Diego Padres | -235 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -115 |
| Cincinnati Reds - 1I | -115 |
| Boston Red Sox vs Seattle Mariners | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Washington Nationals vs Baltimore Orioles | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
| New York Mets vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Phillies | -138 |
| New York Mets | +115 |
| Minnesota Twins vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Over | -120 |
| Under | +100 |
| Chicago Cubs vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Dodgers | -118 |
| Chicago Cubs | -102 |
| Kansas City Royals vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Houston Astros vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Houston Astros - 1H | -110 |
| Toronto Blue Jays - 1H | -120 |
| Los Angeles Angels vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Angels | -195 |
| Pittsburgh Pirates | +160 |
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| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1I | +115 |
| Arizona Diamondbacks - 1I | -150 |
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| Type: Moneyline - Status: OPEN | |
| San Francisco Giants - 1H | -145 |
| Milwaukee Brewers - 1H | +110 |
| Athletics vs Texas Rangers | |
| Type: Runline - Status: OPEN | |
| Athletics - 1H | -120 |
| Texas Rangers - 1H | -110 |