Phil Hughes found his old form after getting plenty of help in the first inning. Hughes pitched six strong innings for his first win in almost a year and the Minnesota Twins beat the Chicago White Sox 3-1 on Friday night for their first 4-0 start since 1987. Miguel Sano hit an RBI go-ahead double in the sixth, and Chris Gimenez added an RBI double in the seventh for the Twins, who led the majors with 103 losses last season after opening 0-9.
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| Henan Wolves vs Shanghai Eagles | |
| Type: Moneyline - Status: OPEN | |
| Henan Wolves | +265 |
| Shanghai Eagles | -335 |
| Tohoku Rakuten Golden Eagles vs Chiba Lotte Marines | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Hanwha Eagles vs NC Dinos | |
| Type: Runline - Status: OPEN | |
| NC Dinos | +125 |
| Hanwha Eagles | -165 |
| Kiwoom Heroes vs KT Wiz | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -120 |
| Samsung Lions vs Lotte Giants | |
| Type: Runline - Status: OPEN | |
| Lotte Giants | -200 |
| Samsung Lions | +150 |
| TSG Hawks vs Wei Chuan Dragons | |
| Type: Runline - Status: OPEN | |
| TSG Hawks | -200 |
| Wei Chuan Dragons | +150 |
| Saitama Seibu Lions vs Fukuoka SoftBank Hawks | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | -105 |
| Tokyo Yakult Swallows vs Yomiuri Giants | |
| Type: Moneyline - Status: OPEN | |
| Tokyo Yakult Swallows | +120 |
| Yomiuri Giants | -155 |
| CTBC Brothers vs Fubon Guardians | |
| Type: Moneyline - Status: OPEN | |
| CTBC Brothers | -310 |
| Fubon Guardians | +225 |
| Rakuten Monkeys vs Uni-Lions | |
| Type: Moneyline - Status: OPEN | |
| Rakuten Monkeys | -110 |
| Uni-Lions | -120 |
| Philadelphia Phillies vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Miami Marlins - 1H | -115 |
| Philadelphia Phillies - 1H | -115 |
| Detroit Tigers vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals - 1H | -105 |
| Detroit Tigers - 1H | -125 |
| Chicago Cubs vs Arizona Diamondbacks | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks - 1H | -160 |
| Chicago Cubs - 1H | +120 |
| Toronto Blue Jays vs Seattle Mariners | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -105 |
| Texas Rangers vs Los Angeles Dodgers | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -105 |
| Pittsburgh Pirates vs Cleveland Guardians | |
| Type: Moneyline - Status: OPEN | |
| Cleveland Guardians | +141 |
| Pittsburgh Pirates | -170 |
| New York Mets vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| New York Mets - 1H | -180 |
| St. Louis Cardinals - 1H | +135 |
| Baltimore Orioles vs Cincinnati Reds | |
| Type: Runline - Status: OPEN | |
| Baltimore Orioles - 1H | -125 |
| Cincinnati Reds - 1H | -105 |
| Boston Red Sox vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Boston Red Sox - 1H | -300 |
| Chicago White Sox - 1H | +220 |
| Colorado Rockies vs Washington Nationals | |
| Type: Runline - Status: OPEN | |
| Washington Nationals | +115 |
| Colorado Rockies | -135 |
| Tampa Bay Rays vs New York Yankees | |
| Type: Runline - Status: OPEN | |
| Tampa Bay Rays - 1H | -115 |
| New York Yankees - 1H | -115 |
| Houston Astros vs San Diego Padres | |
| Type: Runline - Status: OPEN | |
| San Diego Padres | +140 |
| Houston Astros | -165 |
| Milwaukee Brewers vs Athletics | |
| Type: Moneyline - Status: OPEN | |
| Athletics - 1H | +100 |
| Milwaukee Brewers - 1H | -130 |
| Atlanta Braves vs Minnesota Twins | |
| Type: Runline - Status: OPEN | |
| Atlanta Braves - 1H | -105 |
| Minnesota Twins - 1H | -125 |
| Los Angeles Angels vs San Francisco Giants | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |