Bryce Harper and Manny Machado were picked first and third overall in the 2010 Draft. Both debuted in the Majors just two years later, Harper as a teenager and Machado shortly after his 20th birthday.
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| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| Milwaukee Brewers - 1H | -130 |
| Cleveland Guardians - 1H | +100 |
| Baltimore Orioles vs Minnesota Twins | |
| Type: Runline - Status: OPEN | |
| Minnesota Twins | -185 |
| Baltimore Orioles | +160 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Runline - Status: OPEN | |
| Boston Red Sox | +150 |
| Detroit Tigers | -175 |
| Cincinnati Reds vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Under - 1I | -290 |
| Over - 1I | +210 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Phillies | -158 |
| St. Louis Cardinals | +132 |
| Toronto Blue Jays vs Tampa Bay Rays | |
| Type: Runline - Status: OPEN | |
| Tampa Bay Rays - 1H | -145 |
| Toronto Blue Jays - 1H | +110 |
| New York Mets vs Pittsburgh Pirates | |
| Type: Total - Status: OPEN | |
| Over - 1H | +100 |
| Under - 1H | -130 |
| Atlanta Braves vs Washington Nationals | |
| Type: Total - Status: OPEN | |
| Over - 1H | +100 |
| Under - 1H | -130 |
| Chicago Cubs vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Chicago Cubs | -120 |
| Miami Marlins | +100 |
| Texas Rangers vs Colorado Rockies | |
| Type: Runline - Status: OPEN | |
| Texas Rangers | -110 |
| Colorado Rockies | -110 |
| Houston Astros vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals - 1H | +115 |
| Houston Astros - 1H | -150 |
| Seattle Mariners vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1I | -115 |
| Seattle Mariners - 1I | -115 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Moneyline - Status: OPEN | |
| San Diego Padres - 1I | -170 |
| Los Angeles Angels - 1I | +130 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks | +155 |
| San Francisco Giants | -180 |
| Los Angeles Dodgers vs Athletics | |
| Type: Moneyline - Status: OPEN | |
| Athletics | +167 |
| Los Angeles Dodgers | -204 |