Phillies star Bryce Harper was serenaded with boos by Nationals fans on Opening Day, but got the last laugh with a solo home run in a 7-3 win over his former ballclub.
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| Atlanta Braves vs Arizona Diamondbacks | |
| Type: Total - Status: OPEN | |
| Under - 1I | -275 |
| Over - 1I | +200 |
| St. Louis Cardinals vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals | -131 |
| Kansas City Royals | +109 |
| Chicago White Sox vs Detroit Tigers | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| Toronto Blue Jays vs Philadelphia Phillies | |
| Type: Runline - Status: OPEN | |
| Toronto Blue Jays - 1H | -160 |
| Philadelphia Phillies - 1H | +120 |
| Seattle Mariners vs Baltimore Orioles | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| San Francisco Giants vs San Diego Padres | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | +105 |
| Los Angeles Dodgers vs New York Mets | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Dodgers - 1H | -145 |
| New York Mets - 1H | +110 |
| Pittsburgh Pirates vs Houston Astros | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| Washington Nationals vs Chicago Cubs | |
| Type: Runline - Status: OPEN | |
| Washington Nationals | -130 |
| Chicago Cubs | +110 |
| New York Yankees vs Cleveland Guardians | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1H | -260 |
| Cleveland Guardians - 1H | +190 |
| Tampa Bay Rays vs Texas Rangers | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays | -153 |
| Texas Rangers | +128 |
| St. Louis Cardinals vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1I | -130 |
| Kansas City Royals - 1I | +100 |
| North Carolina (#5) vs Arizona | |
| Type: Runline - Status: OPEN | |
| North Carolina (#5) | -115 |
| Arizona | -115 |
| Louisville vs Miami Florida | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Oregon State (#8) vs Florida State (#9) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Auburn (#4) vs Coastal Carolina (#13) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Duke vs Murray State | |
| Type: Runline - Status: OPEN | |
| Duke | -130 |
| Murray State | +100 |
| LSU (#6) vs West Virginia | |
| Type: Moneyline - Status: OPEN | |
| LSU (#6) | -330 |
| West Virginia | +235 |
| Arkansas (#3) vs Tennessee (#14) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| UCLA (#15) vs UTSA | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
