Cole Hamels picked up the win in his Cubs debut, collected his first hit since 2016, and even got his first at-bat before he took the mound. Chicago gave the lefty a four-run cushion in the first inning, and Willson Contreras added a two-run homer in the eighth to seal the win, splitting the two-game set. Pirates starter Nick Kingham lasted just one inning, while Hamels went five, allowing one unearned run on three hits and striking out nine.
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| Boston Red Sox vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Over - 1H | +100 |
| Under - 1H | -130 |
| Cleveland Guardians vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1I | -110 |
| Cleveland Guardians - 1I | -120 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -115 |
| Cincinnati Reds - 1I | -115 |
| New York Mets vs Philadelphia Phillies | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
| Atlanta Braves vs St. Louis Cardinals | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -105 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| San Francisco Giants - 1H | -105 |
| Milwaukee Brewers - 1H | -125 |
