Cole Hamels picked up the win in his Cubs debut, collected his first hit since 2016, and even got his first at-bat before he took the mound. Chicago gave the lefty a four-run cushion in the first inning, and Willson Contreras added a two-run homer in the eighth to seal the win, splitting the two-game set. Pirates starter Nick Kingham lasted just one inning, while Hamels went five, allowing one unearned run on three hits and striking out nine.
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| LSU (#3) vs Arkansas (#7) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Arizona State vs Houston | |
| Type: Moneyline - Status: SUSPENDED | |
| Arizona State | -290 |
| Houston | +210 |
| California vs Florida State (#2) | |
| Type: Total - Status: OPEN | |
| Under | +100 |
| Over | -130 |
| CS Fullerton vs Hawaii | |
| Type: Runline - Status: OPEN | |
| CS Fullerton | +120 |
| Hawaii | -160 |
| Indiana vs Purdue | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| USC (#25) vs Michigan State | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| CSU Bakersfield vs UC Irvine (#13) | |
| Type: Runline - Status: OPEN | |
| CSU Bakersfield | -115 |
| UC Irvine (#13) | -115 |
| Dorados de Chihuahua vs Acereros de Monclova | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -120 |
| Stanford vs Grand Canyon | |
| Type: Runline - Status: OPEN | |
| Stanford | -110 |
| Grand Canyon | -120 |
| Athletics vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1H | -145 |
| Athletics - 1H | +110 |
| Reno Aces vs Las Vegas Aviators | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | -105 |
| Los Angeles Angels vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Baltimore Orioles | -148 |
| Los Angeles Angels | +124 |
| Arizona Diamondbacks vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| Arizona Diamondbacks | +101 |
| Los Angeles Dodgers | -121 |
| Seattle Mariners vs Toronto Blue Jays | |
| Type: Total - Status: OPEN | |
| Over | -105 |
| Under | -115 |
| Tacoma Rainiers vs Sacramento River Cats | |
| Type: Moneyline - Status: OPEN | |
| Tacoma Rainiers | -125 |
| Sacramento River Cats | -105 |
| Charros de Jalisco vs Tecolotes de los Dos Laredos | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -120 |
| Guerreros de Oaxaca vs Tigres de Quintana Roo | |
| Type: Moneyline - Status: OPEN | |
| Guerreros de Oaxaca | -205 |
| Tigres de Quintana Roo | +145 |
| Conspiradores de Queretaro vs Pericos de Puebla | |
| Type: Moneyline - Status: OPEN | |
| Conspiradores de Queretaro | +110 |
| Pericos de Puebla | -155 |
| Generales De Durango vs Sultanes de Monterrey | |
| Type: Runline - Status: OPEN | |
| Generales De Durango | -120 |
| Sultanes de Monterrey | -120 |
| Cleveland Guardians vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Cleveland Guardians - 1I | +105 |
| Philadelphia Phillies - 1I | -135 |
| Rieleros de Aguascalientes vs Saraperos de Saltillo | |
| Type: Runline - Status: OPEN | |
| Rieleros de Aguascalientes | -150 |
| Saraperos de Saltillo | +105 |
| Olmecas de Tabasco vs Bravos de Leon | |
| Type: Runline - Status: OPEN | |
| Olmecas de Tabasco | +145 |
| Bravos de Leon | -205 |
| Leones de Yucatan vs El Aguila de Veracruz | |
| Type: Runline - Status: OPEN | |
| Leones de Yucatan | +140 |
| El Aguila de Veracruz | -200 |
| Algodoneros del Unión Laguna vs Toros de Tijuana | |
| Type: Moneyline - Status: OPEN | |
| Algodoneros del Unión Laguna | -125 |
| Toros de Tijuana | -115 |