The Cleveland Guardians game against the Chicago White Sox has been postponed because of multiple positive COVID-19 tests within the Guardians organization, MLB announced Wednesday.
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| Tokyo Yakult Swallows vs Yomiuri Giants | |
| Type: Runline - Status: OPEN | |
| Tokyo Yakult Swallows | -150 |
| Yomiuri Giants | +115 |
| Atlanta Braves vs Minnesota Twins | |
| Type: Moneyline - Status: OPEN | |
| Atlanta Braves | -120 |
| Minnesota Twins | +100 |
| Boston Red Sox vs Chicago White Sox | |
| Type: Runline - Status: OPEN | |
| Chicago White Sox - 1H | -110 |
| Boston Red Sox - 1H | -120 |
| Pittsburgh Pirates vs Cleveland Guardians | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Pirates - 1H | -125 |
| Cleveland Guardians - 1H | -105 |
| Philadelphia Phillies vs Miami Marlins | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins | +250 |
| Philadelphia Phillies | -310 |
| Toronto Blue Jays vs Seattle Mariners | |
| Type: Moneyline - Status: OPEN | |
| Seattle Mariners | -119 |
| Toronto Blue Jays | -101 |
| Detroit Tigers vs Kansas City Royals | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | +105 |
| New York Mets vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1I | +110 |
| New York Mets - 1I | -145 |
| Tampa Bay Rays vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays | +130 |
| New York Yankees | -155 |
| Chicago Cubs vs Arizona Diamondbacks | |
| Type: Moneyline - Status: OPEN | |
| Arizona Diamondbacks - 1H | -105 |
| Chicago Cubs - 1H | -125 |
| Texas Rangers vs Los Angeles Dodgers | |
| Type: Total - Status: OPEN | |
| Over - 1H | -125 |
| Under - 1H | -105 |
| Colorado Rockies vs Washington Nationals | |
| Type: Runline - Status: OPEN | |
| Colorado Rockies | -165 |
| Washington Nationals | +140 |
| Los Angeles Angels vs San Francisco Giants | |
| Type: Moneyline - Status: OPEN | |
| San Francisco Giants | -113 |
| Los Angeles Angels | -107 |
| Houston Astros vs San Diego Padres | |
| Type: Total - Status: OPEN | |
| Over - 1H | -110 |
| Under - 1H | -120 |
| Colorado Rockies vs Washington Nationals | |
| Type: Runline - Status: OPEN | |
| Colorado Rockies - 1H | -145 |
| Washington Nationals - 1H | +110 |
