One out away from having their wild-card lead trimmed to one-half game, the San Diego Padres bounced back for a big victory. Khalil Greene homered to left field with one out in the 10th inning to give the struggling Padres a desperately needed 5-4 win over the San Francisco Giants on Friday night. It was the third homer of the game for the Padres, who scored three runs in the last two innings.
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| Colorado Rockies vs Washington Nationals | |
| Type: Total - Status: OPEN | |
| Under - 1I | -215 |
| Over - 1I | +160 |
| Algodoneros del Unión Laguna vs Dorados de Chihuahua | |
| Type: Runline - Status: OPEN | |
| Algodoneros del Unión Laguna | -135 |
| Dorados de Chihuahua | -105 |
| Boston Red Sox vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Over - 1H | -130 |
| Under - 1H | +100 |
| Cleveland Guardians vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1I | -110 |
| Cleveland Guardians - 1I | -120 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -115 |
| Cincinnati Reds - 1I | -115 |
| New York Mets vs Philadelphia Phillies | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
| Atlanta Braves vs St. Louis Cardinals | |
| Type: Total - Status: OPEN | |
| Over | +100 |
| Under | -120 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| San Francisco Giants - 1H | -105 |
| Milwaukee Brewers - 1H | -125 |
