Regular-season games will return on Thursday, with all 30 teams in action to begin the 2018 season. With that in mind, and based upon who is expected to be in the lineup, here is a look at the players at each defensive position who have the longest active streaks of Opening Day starts for the same team.
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| Baltimore Orioles vs Minnesota Twins | |
| Type: Runline - Status: OPEN | |
| Minnesota Twins | -200 |
| Baltimore Orioles | +170 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Runline - Status: OPEN | |
| Philadelphia Phillies | +115 |
| St. Louis Cardinals | -135 |
| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Total - Status: OPEN | |
| Over - 1H | -110 |
| Under - 1H | -120 |
| Baltimore Orioles vs Minnesota Twins | |
| Type: Moneyline - Status: OPEN | |
| Baltimore Orioles | -130 |
| Minnesota Twins | +108 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Moneyline - Status: OPEN | |
| Arizona Diamondbacks | -110 |
| San Francisco Giants | -110 |
| Seattle Mariners vs New York Yankees | |
| Type: Total - Status: OPEN | |
| Over - 1H | +100 |
| Under - 1H | -130 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Total - Status: OPEN | |
| Under - 1I | -340 |
| Over - 1I | +240 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Total - Status: OPEN | |
| Under | +105 |
| Over | -125 |
| Toronto Blue Jays vs Tampa Bay Rays | |
| Type: Total - Status: OPEN | |
| Over - 1H | -110 |
| Under - 1H | -120 |
| New York Mets vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Pirates - 1H | +190 |
| New York Mets - 1H | -260 |
| Cincinnati Reds vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati Reds | -230 |
| Chicago White Sox | +190 |
| Atlanta Braves vs Washington Nationals | |
| Type: Moneyline - Status: OPEN | |
| Atlanta Braves - 1I | -150 |
| Washington Nationals - 1I | +115 |
| Chicago Cubs vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Chicago Cubs - 1H | +100 |
| Miami Marlins - 1H | -130 |
| Texas Rangers vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over | -105 |
| Under | -115 |
| Houston Astros vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals | +115 |
| Houston Astros | -138 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Total - Status: OPEN | |
| Over - 1I | +210 |
| Under - 1I | -290 |
| Los Angeles Dodgers vs Athletics | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
