The Detroit Tigers face the Toronto Blue Jays on March 18, 2021, in a spring training game.
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| Miami Marlins vs Colorado Rockies | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -145 |
| Colorado Rockies - 1I | +110 |
| Cincinnati Reds vs Milwaukee Brewers | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati Reds | -120 |
| Milwaukee Brewers | +100 |
| Boston Red Sox vs Los Angeles Angels | |
| Type: Runline - Status: OPEN | |
| Boston Red Sox | +150 |
| Los Angeles Angels | -175 |
| Pittsburgh Pirates vs Houston Astros | |
| Type: Total - Status: OPEN | |
| Under - 1H | -105 |
| Over - 1H | -125 |
| Washington Nationals vs Chicago Cubs | |
| Type: Moneyline - Status: OPEN | |
| Washington Nationals - 1I | -115 |
| Chicago Cubs - 1I | -115 |
| New York Yankees vs Cleveland Guardians | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| Toronto Blue Jays vs Philadelphia Phillies | |
| Type: Total - Status: OPEN | |
| Under | +100 |
| Over | -120 |
| Atlanta Braves vs Arizona Diamondbacks | |
| Type: Moneyline - Status: OPEN | |
| Atlanta Braves - 1H | -190 |
| Arizona Diamondbacks - 1H | +145 |
| Tampa Bay Rays vs Texas Rangers | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays | -142 |
| Texas Rangers | +119 |
| Chicago White Sox vs Detroit Tigers | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| St. Louis Cardinals vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1I | -135 |
| Kansas City Royals - 1I | +105 |
| Seattle Mariners vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Seattle Mariners - 1H | -125 |
| Baltimore Orioles - 1H | -105 |
| San Francisco Giants vs San Diego Padres | |
| Type: Total - Status: OPEN | |
| Under - 1I | -410 |
| Over - 1I | +280 |
| Athletics vs Minnesota Twins | |
| Type: Moneyline - Status: OPEN | |
| Athletics | +115 |
| Minnesota Twins | -138 |
| Los Angeles Dodgers vs New York Mets | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |