Allowing only Francisco Lindor’s third-inning solo home run, Gerrit Cole struck out 12 Indians in seven dominating innings to lead the Astros to a 2-0 lead in the best-of-five American League Division Series. Marwin Gonzalez, who recorded four hits, drilled a go-ahead two-run double in the sixth off Andrew Miller, who had just entered in relief of Carlos Carrasco, before Alex Bregman hit his second homer of the ALDS in the seventh, off Trevor Bauer. Roberto Osuna sealed the victory with a four-out save.
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| North Carolina (#5) vs Arizona | |
| Type: Runline - Status: OPEN | |
| North Carolina (#5) | -115 |
| Arizona | -115 |
| Tampa Bay Rays vs Miami Marlins | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1H | -160 |
| Miami Marlins - 1H | +120 |
| Louisville vs Miami Florida | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Oregon State (#8) vs Florida State (#9) | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Pittsburgh Pirates vs Philadelphia Phillies | |
| Type: Runline - Status: OPEN | |
| Pittsburgh Pirates | -140 |
| Philadelphia Phillies | +120 |
| Washington Nationals vs Texas Rangers | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| New York Yankees vs Boston Red Sox | |
| Type: Total - Status: OPEN | |
| Under - 1H | -130 |
| Over - 1H | +100 |
| Detroit Tigers vs Chicago Cubs | |
| Type: Runline - Status: OPEN | |
| Detroit Tigers - 1H | -125 |
| Chicago Cubs - 1H | -105 |
| Cincinnati Reds vs Arizona Diamondbacks | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati Reds | -103 |
| Arizona Diamondbacks | -117 |
| Cleveland Guardians vs Houston Astros | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Chicago White Sox vs Kansas City Royals | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Milwaukee Brewers vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| Milwaukee Brewers - 1I | -145 |
| San Diego Padres - 1I | +110 |
| Minnesota Twins vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Minnesota Twins | -155 |
| Toronto Blue Jays | +130 |
| St. Louis Cardinals vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1H | -150 |
| Los Angeles Dodgers - 1H | +115 |
| Colorado Rockies vs New York Mets | |
| Type: Runline - Status: OPEN | |
| Colorado Rockies - 1H | +115 |
| New York Mets - 1H | -150 |
| Auburn (#4) vs Coastal Carolina (#13) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Los Angeles Angels vs Seattle Mariners | |
| Type: Runline - Status: OPEN | |
| Los Angeles Angels - 1H | -130 |
| Seattle Mariners - 1H | +100 |
| Athletics vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Athletics - 1H | +105 |
| Baltimore Orioles - 1H | -135 |
| San Francisco Giants vs Atlanta Braves | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Duke vs Murray State | |
| Type: Runline - Status: OPEN | |
| Duke | -130 |
| Murray State | +100 |
| LSU (#6) vs West Virginia | |
| Type: Moneyline - Status: OPEN | |
| LSU (#6) | -330 |
| West Virginia | +235 |
| Arkansas (#3) vs Tennessee (#14) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| UCLA (#15) vs UTSA | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |